Monosomy for a G autosome.

Monosomy for a G autosome.

Infants with complete or partial deletion of a G group autosome and of similar appearance have -been described by Lejeune et al. (1964), Reisman et al. (1966), and Thorburn and Johnson (1966). The infant with many congenital abnormalities reported by Lejeune et al. (1964) had a karyotype with autosomal mosaicism, involving a chromosome of the G group. One cell line was monosomic with 45 chromos...

Apparent monosomy of a G autosome in a Jamaican infant.

Monosomy of an autosome is widely thought to be lethal (Patau, I963). Deficiencies due to deletions of chromosomes I8 and 5 are well documented (de Grouchy, Lamy, Thieffry, Arthuis, and Salmon, I963; Lejeune, Lafourcade, Berger, Vialatte, Boeswillwald, Seringe, and Turpin, I963), and reciprocal translocations which can arise in a carrier person and result in unbalanced offspring with duplicatio...

Monosomy G: case report and review of the literature.

G-CSF and monosomy 7 in marrow failure patients

Kojima and colleagues (page 786) report a correlation between G-CSF treatment of children with aplastic anemia and evolution to cytogenetic abnormalities and myelodysplasia. How strong is this relationship and how generalizable the conclusions? The Japanese investigators administered high G-CSF doses (close to the adult equivalent of 10 g/kg/d, later thrice weekly) for very long periods (in all...

A case report of Monosomy 21

monosomy 21 is a rare chromosomal abnormality which is persented in mosaic or homogenous forms.the latter form which is very rare,is determined by intra uterin growth retardation)IUGR),failure to thrive (FTT),prominent craniofacial,skeletal deformities and differnt degrees of delay in psychomotor activities.we report an eight years old boy who was admitted in pediatric ward(hospital No 1 of Ker...